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For frequent heartburn

Nexium® 24HR is now covered at the generic co-pay for more than 10 million patients.1
Managed Markets Insight &
Technology, LLC, databases as
of October 2015.

To ensure your patients get
The Purple Pill® they want and trust for frequent heartburn, make sure to write “Nexium® 24HR dispense as written (DAW)” on their prescription.

Check with your patient's plan to see if
Nexium® 24HR (esomeprazole 20 mg) is covered, so they can obtain it at the generic co-pay.
Nexium 24HR
Use as directed.
Give your frequent heartburn patients the #1 prescribed acid blocker brand today!2*
IMS Health. National Prescription
Audit; 2013.
*Based on IMS Heath data:total NEXIUM® prescriptions 2002-2012. Nexium® 24HR is available without a prescription for the treatment of frequent heartburn.
Get more information on how to prescribe Nexium® 24HR

When you prescribe Nexium® 24HR, remember to indicate “dispense as written.”

Writing “Nexium® 24HR dispense as written (DAW)” guarantees your patients will receive The Purple Pill® they want and trust for frequent heartburn when picking up their prescription.
Learn about Nexium® 24HR acid control data
Based on a recent analysis of post hoc studies

Patients obtained better pH control during daytime hours with Nexium® 24HR than with other OTC proton-pump inhibitors.3
Katz P, Kahrilas PJ, Johnson DA,
et al. Daytime intragastric acid
control: post hoc analyses of
esomeprazole 20 mg and
over-the-counter proton-pump
inhibitors. Therap Adv
. 2015;8(6):322-330.

Study Chart

The above chart compares the mean percentage (95% Cl) of the 14-hour daytime period with intragastric pH > 4 for Nexium® 24HR (esomeprazole 20 mg) with other over-the-counter proton-pump inhibitors (PPis).

*Pantoprazole 20 mg is not available OTC in the United States.

Adapted from Katz P, et al. Therap Adv Gastroenterol. 2015;8(6):322-330.


Acid reflux disease typically occurs during the day. These post hoc analyses attempted to determine the level of intragastric pH control during the daytime period and whether there were improvements resulting from esomeprazole 20 mg (the equivalent of Nexium® 24HR) versus over-the-counter proton-pump inhibitors.


lntragastric pH was assessed for 24 hours over 5 treatment days in one double-blind and 3 open-label, randomized, crossover studies.


lntragastric pH levels were maintained at >4 for a significantly greater mean percentage of the 14-hour daytime period with esomeprazole 20 mg compared with the other PPI comparators, which were all taken at OTC doses. Geometric mean ratios* (95% confidence intervals) for esomeprazole 20 mg versus the comparators were:

  • 1.45 (1.14-1.85; P = 0.003) versus omeprazole 20 mg (the equivalent of Prilosec® OTC)
  • 2.50 (2.01-3.11; P < 0.0001) versus pantoprazole 20 mg (the equivalent of Protonix)
  • 1.69 (1.46-1.97; P < 0.0001) and 1.89 (1.05-3.37; P = 0.03) versus lansoprazole 15 mg (the equivalent of Prevacid® 24HR)
*Geometric mean ratio is in regards to the proportion of time with acid control.


Data from post hoc studies demonstrated that patients managing gastroesophageal reflux disease obtained better pH control during daytime hours with esomeprazole than with OTC proton pump inhibitors.

Have questions about Nexium® 24HR?


Who should take Nexium® 24HR?
Adults who are 18 years of age or older with frequent heartburn (2 or more days per week) can take Nexium® 24HR. It is important to read and carefully follow the labeling directions for use of Nexium® 24HR. Those who should not take
Nexium® 24HR include4
Nexium® 24HR Drug Facts.
Pfizer Inc, 2014.

  • Children younger than 18 years of age
  • People who have 1 episode or less of heartburn per week
  • Those who want immediate relief from heartburn. Nexium® 24HR is a proactive treatment for frequent heartburn, and should be taken before symptoms occur to potentially lessen the effects of future heartburn episodes
  • People with known hypersensitivity to esomeprazole magnesium or any of the ingredients in Nexium® 24HR
  • People who have trouble or pain swallowing food, vomiting with blood, or bloody or black stools, as these may be signs of a serious condition
What is the indication for Nexium® 24HR, and how does it differ from the indications for the prescription formulation?

Unless a physician prescribes otherwise, Nexium® 24HR (esomeprazole 20 mg) is indicated for the treatment of frequent heartburn in adults 18 years of age or older, once a day (every 24 hours), every day for 14 days.

Nexium® (esomeprazole) is available by prescription (20 mg and 40 mg) and is indicated for the treatment of gastroesophageal reflux disease (GERD), risk reduction of NSAID-associated gastric ulcer, H. pylori eradication to reduce the risk of duodenal ulcer recurrence, and pathological hypersecretory conditions, including Zollinger-Ellison syndrome.5
Nexium® [package insert].
Wilmington, DE: AstraZeneca
LP; 2014.
What is the ICD-10 code for heartburn?

Previously, the ICD-9 code for heartburn was 787.1 - Heartburn. With the conversion to ICD-10 diagnosis codes, the new entry for heartburn is R12.

What is the co-pay for Nexium® 24HR?

Nexium® 24HR has Tier 1 coverage on some health plans, meaning patients can receive it for the generic co-pay. This co-pay amount can range from $0 to $10, depending on the plan.

What if my patient doesn't have coverage for Nexium® 24HR on their health plan?

If your patient's health plan does not cover Nexium® 24HR, click here for coupons and samples. Nexium® 24HR is still available to all of your patients over the counter.