Adapted from Katz P, et al. Therap Adv Gastroenterol. 2015;8(6):322-330.
Acid reflux disease typically occurs during the day. These post hoc analyses attempted to determine the level of intragastric pH control during the daytime period and whether there were improvements resulting from esomeprazole 20 mg (the equivalent of Nexium® 24HR) versus over-the-counter proton-pump inhibitors.
lntragastric pH was assessed for 24 hours over 5 treatment days in one double-blind and 3 open-label, randomized, crossover studies.
lntragastric pH levels were maintained at >4 for a significantly greater mean percentage of the 14-hour daytime period with esomeprazole 20 mg compared with the other PPI comparators, which were all taken at OTC doses. Geometric mean ratios* (95% confidence intervals) for esomeprazole 20 mg versus the comparators were:
Data from post hoc studies demonstrated that patients managing gastroesophageal reflux disease obtained better pH control during daytime hours with esomeprazole than with OTC proton pump inhibitors.
Unless a physician prescribes otherwise, Nexium® 24HR (esomeprazole 20 mg) is indicated for the treatment of frequent heartburn in adults 18 years of age or older, once a day (every 24 hours), every day for 14 days.Nexium® (esomeprazole) is available by prescription (20 mg and 40 mg) and is indicated for the treatment of gastroesophageal reflux disease (GERD), risk reduction of NSAID-associated gastric ulcer, H. pylori eradication to reduce the risk of duodenal ulcer recurrence, and pathological hypersecretory conditions, including Zollinger-Ellison syndrome.5
Previously, the ICD-9 code for heartburn was 787.1 - Heartburn. With the conversion to ICD-10 diagnosis codes, the new entry for heartburn is R12.
Nexium® 24HR has Tier 1 coverage on some health plans, meaning patients can receive it for the generic co-pay. This co-pay amount can range from $0 to $10, depending on the plan.